Bone Scintigraphy of Vertebral Fractures With a Whole-Body CZT Camera in a PET-Like Utilization

Objective: An image display with a standardized uptake value (SUV) scale is recommended for analyzing PET exams, thus requiring the reconstruction of accurate images both SUV measurement and visual analysis. This study aimed to determine whether such may also be obtained high-speed CZT-SPECT/CT system, further application longitudinal monitoring vertebral fractures. Materials Methods: SPECT was optimized an IEC phantom according quality parameters accuracy measured activity. The process applied ≤15 min 99m Tc-HDP spine recordings previously acquired from 25 patients (74 ± 12 years old) at early (1.3 1.1 months) late (5.2 2.3 stages after acute fracture. Results: A 32 equivalent iterations selected based on association high detectability spheres down 0.6 ml in volume, activity, although latter affected by partial volume effect ≤5.6 ml. Coherent measurements were these high-quality SUVmax intact vertebrae patients, which stable between basal SPECT/CT follow-up (for T1 vertebrae: 5.7 vs. 5.8 1.1, p = 0.76), initially fractured vertebrae, dramatically higher compared (21.0 8.5 11.2 4.2, < 0.001), whereas inverse changes observed newly compacted fractures identified (74.4 2.0 21.8 10.3, 0.002). Finally, shown advantageous highlighting areas >7.5 SUV, level reached 98% <7 months 4% reference vertebrae. Conclusion: Bone scintigraphy this system fast 3D acquisitions displayed reliable scale, approaching what achieved imaging.